Imaging Engineering Tissue
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A core challenge being addressed by the Imaging Thrust of the CELL MET Engineering Research Center is to answer the question: In engineered tissue platforms, how do we do volumetric imaging over wide fields of view with high resolution and at high speed? In this talk I will discuss the problem generically, beginning with three strategies for imaging volumetrically: widefield, confocal, and multiphoton microscopy. I will describe progress that we have made in particular for imaging modalities that are useful for engineered cardiac tissue. I will discuss the use of recently-engineered fluorescent voltage sensors to allow millisecond-scale temporal resolution in microscopy, and the advanced microscopes that we have been using to explore tissue structures. Finally, I will talk about cardiac micro tug (µTug) imaging and our progress in developing platforms for high-throughput screening, force measurement and control with optical feedback, and an all-optical non-contact tool for measuring tissue stiffness.
Dr. Thomas Bifano earned his Ph.D. in Mechanical Engineering from North Carolina State University and his M.S. and B.S. in Mechanical Engineering and Materials Science from Duke University. He has been a Professor at Boston University since 1988.
Dr. Bifano’s research focuses on modeling, design, production, and use of micro-electro-mechanical systems (MEMS) in optical applications. He is a founder and CTO of Boston Micromachines Corporation in Cambridge, MA, a leading producer of deformable mirrors for applications in astronomy, bio-imaging, and defense.
Zoom Link: https://bostonu.zoom.us/j/93315594357?pwd=eE4wQS9lZjA2aloyMkQ2dG5CS21kZz09
Meeting ID: 933 1559 4357, Passcode: 689715